In vivo and in vitro studies on drug metabolism and interactions involving mibefradil, isradipine, lidocaine, selegiline and metronidazole
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منابع مشابه
Formulation Design and Evaluation of Hydrogel-Based Metronidazole Bioadhesive Tablet for Vaginal Candidiasis
Hydrogel Based Metronidazole Bioadhesive Tablet (HMBT) was prepared as a novel vaginal delivery system to achieve Controlled release of drug from the tablet for vaginal candidiasis. The highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by SEM, DSC and FT-IR and evaluated for % ...
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متن کاملDevelopment and Characterization of Bioadhesive Gel of Microencapsulated Metronidazole for Vaginal Use
The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...
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متن کاملQuantitative prediction of mechanism-based inhibition caused by mibefradil in rats.
It was previously demonstrated that mibefradil, which shows mechanism-based inhibition in humans, also caused drug-drug interactions (DDIs) with midazolam (MDZ) in rats. In this study, we aimed to quantitatively predict the DDIs observed in rats using a physiologically based pharmacokinetic (PBPK) model from in vitro inactivation parameters. For more precise predictions, contribution ratios of ...
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